Szablowski et al. 2018 Nature Biomedical Engineering
<概要>
これまで、血液脳関門通過が困難な薬剤の脳内送達等には侵襲的な方法が主に用いられてきたが、acoustically targeted chemogenetics (ATAC)を用いることで非侵襲的に、かつ、細胞特異的に薬物等を送達することができる。ATACとは、超音波＋アデノ随伴ウイルス＋低分子化合物を組み合わせることで、各itemの長所が短所を補うことで相乗的な効果を生み出している治療法である。
"Acoustically targeted chemogenetics for the non-invasive control of neural circuits"
Szablowski et al. 2018 Nature Biomedical Engineering
<Summary>
Until now, invasive methods have been mainly used for intracerebral delivery of drugs that are difficult to cross the blood-brain barrier. Here, non-invasively and cell-specifically using acoustically targeted chemogenetics (ATAC) is reported to deliver a drug or the like. ATAC is a treatment that produces a synergistic effect by combining the advantages of each item with the shortcomings by combining ultrasound + adeno-associated virus + low molecular weight compounds.
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