Drug development
【紹介文献】 Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route Jia et al., 2022, Mol. Ther. Nucleic Acids https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162…
mesothelinに対する抗体薬物複合体の話題 【Summary】 In the next Science Café, I will give the topic of antibody-drug conjugate directed against mesothelin. It comprises an anti-mesothelin fully human IgG1 monoclonal antibody connected to a …
"Drug discovery for intrinsically disordered protein" 【紹介文献】 Intrinsically disordered proteins/regions and insight into their biomolecular interactions Chakrabarti, et al., Biophys Chem. 2022 Apr;283:106769. www.sciencedirect.com Mol…
The possibilities of oral use of peptide drug and other new modalities 【紹介文献】 "Advances in oral peptide drug nanoparticles for diabetes mellitus treatment" Yan Li et al, Bioactive Materials 15 (2022) 392–408. www.sciencedirect.com "C…
【紹介文献】 mRNA-based therapeutics: powerful and versatile tools to combat diseases Qin et al. Signal Transduction and Targeted Therapy volume 7, Article number: 166 (2022) www.nature.com 【発表概要】 今回のサイエンスカフェではmRNA治療薬…
【紹介文献】 "An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19" Owenet al., 2021, Science, 374, 1586 www.science.org 【発表概要】 今回のサイエンスカフェでは、ファイザー社によるコロナウイルス治療薬の開発の…
