【紹介文献】
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
Hwang et al., 2022, Nat. Commun.
【発表概要】
サイエンスカフェ前半ではRNA結合タンパク質(RNABP)について概要を紹介し、後半ではオートファジーにおいて中心的な役割を果たすLC3Bの新たな機能―RNA制御因子としての役割―を紹介する。
【Summary】
The first half of this presentation will give an overview of RNA-binding proteins (RNABPs), and the second half will introduce a new function of LC3B, which plays a central role in autophagy - as an RNA regulator. LC3/ATG8 plays a central role in autophagy, and now we know that LC3B is an RNABP and binds directly to the AAUAAA motif, which is well known polyadenylation reaction signal in mRNAs. LC3B triggers rapid degradation of target mRNAs in CCR4-NOT deadenylation complex-dependent manner and plays a role in autophagy.
(2022.12.15 Shonan iPark Science Cafe 134th)
発表資料: