【紹介文献】
"Reconstituted Human Organ Models as a Translational Tool for Human Organ Response: Definition, Expectations, Cases, and Strategies for Implementation in Drug Discovery and Development"
Tetsuka et al, Biological and Pharmaceutical Bulletin 2020 年 43 巻 3 号 p. 375-383
【発表概要】
今回のサイエンスカフェでは“再構築ヒト臓器モデル”について話題提供します。近年、organ-on-chip, microphysiological system, organoidなど、ヒト細胞の培養法に関する新しい方法や概念が生まれてきています。紹介する論文においては、これらの技術を用いて作成した培養系を“ 再構築ヒト臓器モデル”と定義し、創薬への貢献可能性について議論されています。前半ではその定義や創薬への利用可能性、後半はデータ例や課題などについて紹介します。
【Summary】
In the next Science Café, I will give a topic of ‘reconstituted human organ models’ to attendees.
Recent progress in cell culture technology has led to increasing focus on ways to use this emerging technology in the pharmaceutical industry for drug discovery and development. Indeed, several buzzwords have arisen in the field, including three dimensional (3D) culture, spheroid culture, microphysiological system (MPS), organ-on-a-chip, body-on-a-chip, organoid, and organoid-on-a-chip. The journal applied the concept of the reconstituted human organ model to these terms. In this café, I will introduce such concept and compare them with other human organ models. I will also describe a case study on the use of a reconstituted human organ model of the liver, and future challenges.
(2021.2.18 iPark Science Cafe 66th)
