A part of direct conversion technology of non-neuronal cells into neurons in vivo
【紹介文献】
"Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB"
Maimon R et al., Nat Neurosci. 2021 24. 1089-1099.
"Revisiting astrocyte to neuron conversion with lineage tracing in vivo"
Wang LL et al., Cell. 2021 S0092-8674 01052-7.
【発表概要】
Adult brainで神経が新たに生み出される割合は極めて低いと考えられていたものの，高効率的にin vivoで神経を生み出す技術が登場している。PTB1 (polypyrimidine tract binding protein 1)をたった一つノックダウンするだけでアストロサイトが目的の神経にin vivoで転換すると示したいくつかの論文を紹介する。一方で，成功したこれら論文に対して慎重な解釈・精査が必要と述べる別グループの結果も紹介できればと考えております。
【Summary】
Although it is thought that neurogenesis in adult brains was extremely low except in certain regions, highly efficient reprogramming (or direct conversion of non-neuronal cells into neurons) technologies have emerged. There have been a number of papers showing that knockdown of PTB1 (polypyrimidine tract binding protein 1) reprograms astrocytes into neurons. On the other hand, some scientists reports careful interpretations and results.
(2021.10.21 iPark Science Cafe 93rd)
