“Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats”
Goto et al., 2019, Nature Communications,10, 451
【発表概要】
近年，透析を要する慢性腎不全患者数が増加傾向ですが，最も有効な根治治療である腎移植に関して，圧倒的なドナー腎不足が課題となっております．ドナー腎不足の解決に向けて，ヒトiPS細胞から腎臓を作製する試みがなされていますが，未だ移植に堪えうる腎臓の作製には至っておりせん．
今回のサイエンスカフェでは，ヒト由来の腎臓作製を目指した研究の一例として，異種胚盤胞置換法を用いた，ラットにおけるマウスES細胞由来腎臓の作製に関する研究について紹介したいと思います．本研究の応用として，ヒトと臓器サイズが近いブタを用いたヒト細胞由来腎臓の作製が期待されますが，それに関連したトピックスも併せて紹介します．
【Summary】
In recent years, the number of patients with chronic renal failure who require dialysis has been increasing. However, renal transplantation, which is the most effective curative treatment, has an overwhelming donor kidney shortage. Attempts have been made to produce kidneys from human iPS cells to resolve kidney shortage, but we have not yet produced kidneys from iPS cells that can be available for transplantation.
In this Science Cafe, I would like to introduce a study on generation of mouse ES-derived kidney in rat using interspecific blastocyst complementation between mouse and rats. As an application of this research, I will also introduce topics related to human cell-derived kidneys using pigs whose organ size is close to that of humans.
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(2020.02.13 iPark Science Cafe 27th)
